Acromegaly Associated with Leukemia: A Case Report

Acromegaly is one of the most common clinical presentations of pituitary tu-mors. some patients with this condi-tion may be affected by other benign or malignant neoplasms. there are a few reports of acromegaly in association with acute leukemias.case report: reported here is a case of acromega-ly associated with philadelphia positive acute lymphoblastic leukemial. the patient was a 61 year-old man, evaluated for complaints of bleed-ing from pilonidal cyst and weakness. he had typical acromegalic features. laboratory tests showed he had pancytopernia and elevated igf-1 levels. imaging studies revealed he had a pitui-tary macroadenoma. the result of aspiration and biopsy of bone marrow and flowcytometric analysis confirmed the diagnosis of acute lym-phoblastic leukemia, pre b cell type. cytogenetic study of lymphoblasts revealed translocation of the 9 and 22 or philadelphia chromosome.conclusion: it is suggested that the proliferative effect of growth hormone, as well as its anti-apoptotic activity related to igf-1 may result in the increased incidence of neoplastic processes including acute leukemias in this group of pa-tients.