Trends of Serum Thyrotropin Concentration and Associated Factors in Urban Pakistan (Karachi)

This investigation aimed at assessing trends of tsh levels and associated factors in apparently normal subjects of urban pakistan (karachi).materials and methods: the survey was conducted in 2004 in lyari, karachi. using a geographical imaging system, 85, 520 households were identified, of which 532 were randomly se-lected; 867 adults aged ≥25 years consented to take part in the study. blood samples from 324 subjects were available for analyses. subjects with previous history of thyroid disorders were excluded. results uconclusionu: this spectrum of tsh levels highlighted a high prevalence of increased serum tsh levels in the population studied, a trend that was associated with obesity and various lipid abnormalities. further population based studies are needed to correlate these findings with clinical parameters of hypothyroidism.