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logic regression analysis of gene polymorphisms and hdl levels in a nationally representative sample of iranian adolescents: the caspian-iii study
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نویسنده
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moghadasi mehri ,kelishadi roya ,marateb hamid reza ,haghjooy javanmard shaghayegh ,mansourian marjan ,heshmat ramin ,motlagh mohammad esmaeil
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منبع
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international journal of endocrinology and metabolism - 2017 - دوره : 15 - شماره : 3 - صفحه:1 -8
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چکیده
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Background: to investigate the associations of genetic polymorphism with high-density lipoprotein-cholesterol (hdl-c) levels in iranian adolescents. methods: this multicentre study was conducted on 10 - 18 year-old students from 27 provinces in iran. logic regression approach was used to determine the main effects and interactions of polymorphisms related to hdl-c levels. results: the rs708272 polymorphism was significantly related to hdl-c levels. moreover, rs708272 increased hdl-c levels and had a protective effect on hdl-c. the interaction of rs2230808 and rs5880 polymorphisms as well as the interaction of rs320 and rs708272 polymorphisms were associated with lower hdl-c levels. furthermore, the interaction of rs320 and rs1801177 polymorphisms was associated with lower hdl-c levels. conclusions:we found that not only single snps, but also interactions of several snps affect hdl-c levels. given the high prevalence of low hdl-c in middle eastern populations, further genetic studies are required for detailed analysis.
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کلیدواژه
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polymorphism ,high-density lipoprotein ,pediatrics ,logic regression
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آدرس
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isfahan university of medical sciences, school of health, student research center, biostatistics and epidemiology department, ایران, isfahan university of medical sciences, child growth and development research center, pediatrics department, ایران, university of isfahan, faculty of engineering, biomedical engineering department, ایران. universitat politècnica de catalunya, barcelonatech (upc), biomedical engineering research center, department of automatic control, spain, isfahan university of medical sciences, applied physiology research center, physiology department, ایران, isfahan university of medical sciences, child growth and development research center, applied physiology research center, faculty of health, pediatrics department, physiology department, biostatistics and epidemiology department, ایران, tehran university of medical sciences, endocrinology and metabolism population sciences institute, chronic diseases research center, ایران, ahvaz jundishapur university of medical sciences, pediatrics department, ایران
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Authors
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