pharmacological treatment in diabetes mellitus type 1 - insulin and what else?

The basis of treatment in autoimmune diabetes is insulin therapy; however, many clinical cases have proven that this method does not solve all problems. trials of causal treatment including blocking the autoimmune processes and insulinproducing cells transplants were carried out. those methods require more research to be concerned as efficient and safe ways of treatment in type 1 diabetes. the use of noninsulin adjunct treatment is a new trend. it has been successfully used in laboratories as well as clinical trials. metformin is the most widely used drug, together with sodiumglucose cotransporters 2 (sglt2) inhibitors, amylin analogues, glucagonlike peptide 1 (glp1) receptor agonists, and dipeptidyl peptidase4 (dpp4) inhibitors. the results of administration of these medicaments give good outcomes in patients with diabetes mellitus type 1. most likely, in the near future, they will progressively be used in both adult and adolescent patients with type 1 diabetes. further multicenter, randomized studies are required to evaluate the efficacy of treatment and long term safety of these drugs.