Lipids, Apolipoproteins, Lipid Oxidation and Paraoxonase Enzyme Activity in Diabetic and Non- Diabetic End Stage Renal Disease Patients

Paraoxonase (pon) is a serum esterase,associated with hdl-c. it decreases the oxidation of ldl-c. serum pon1 activity has been shown to diminish in several diseases. we investigated theserum pon1 activity and lipid profiles in diabetic and non-diabetic end stage renal disease (esrd) patients and controls as well as serumpon1 activity pre and post dialysis. materials and methods: for this study we recruited 92 patients with esrd on hemodialysis,and 46 healthy controls. the patients were assigned into diabetic and non-diabetic groups (each, n=46 each). serum lipid profiles includingtotal cholesterol, triglycerides, hdl-c, apolipoprotein a-1, apolipoprotein b, lipoprotein (a) serum pon activity, oxidized ldl-c and total antioxidant capacity were compared among groups.furthermor e, pre and post dialysis serum pon activity were also compared. results: serum levels of total cholesterol, hdlc,ldl-c and apoa-i were lower in the esrd patients, compared to controls. while serum pon activity was significantly lower in theesrd than in controls, it did not differ significantly between diabetic and non-diabetic patients with esrd. serum pon activity was observed to rise significantly postdialysis, compared to predialysis,69±48 vs. 72±50 iu/ml and 47±32 vs. 53±37 iu/ml in diabetic and non- diabetic patients respectively, the increase being significantly correlated with the quality of hemoidalysis. conclusion: to conclude, reduced serum paraoxonase activity in diabetes and non-diabetesesrd may further predispose lipids to oxidation. enhancement of the quality of hemodialysis can increase serum pon activity in hemodialysispatients.