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Evaluation of Antipyretic Activity of Pedalium murex Against Brewer’s Yeast-Induced Pyrexia in Rats
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نویسنده
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Siva V. ,Jeffrey Bose N.J ,Mehalingam P. ,Thanga Thirupathi A.
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منبع
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journal of ornamental plants - 2012 - دوره : 2 - شماره : 2 - صفحه:131 -137
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چکیده
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The aqueous and ethanolic extracts of pedalium murex (pedaliaceae)was investigated for antipyretic activity in rats using brewer’s yeast-inducedpyrexia models. brewer’s yeast (15%) was used to induce pyrexia in rats. boththe extract (200 and 400 mg/kg body weight p.o produced a significant(p < 0.05) dose dependent inhibition of temperature elevation compared withthe standard drug paracetamol (150mg/kg body weight). at doses of 200mg/kg b.w, the aqueous extract significantly (p < 0.001) decreased yeast inducedpyrexia in rats. these results indicate that leaf extracts of pedalium murexpossesses potent antipyretic effects and thus pharmacologically justifying itsfolkloric use in the management of fever.
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کلیدواژه
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Acute toxicity ,Antipyretic ,Brewer’s yeast ,Prost
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آدرس
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Research Department of Botany, V.H.N.Senthikumara Nadar College, Virudhunagar, Tamil Nadu, India. Phone: 04562-280154 Fax: 04562-281338., India, Research Department of Botany, V.H.N.Senthikumara Nadar College, Virudhunagar, Tamil Nadu, India. Phone: 04562-280154 Fax: 04562-281338., India, Research Department of Botany, V.H.N.Senthikumara Nadar College, Virudhunagar, Tamil Nadu, India. Phone: 04562-280154 Fax: 04562-281338., India, Department of Pharmacology, SankaralingamBhuvaneswari College of Pharmacy, Sivakasi, Tamil Nadu, India., India
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Authors
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