Comparison of two different methods of colon cleansing for afternoon-colonoscopy

Background: the appropriate colon cleansing is a major determinant of quality of colonoscopy. this prospective randomized study was designed to compare the efficacy and tolerability of the morning (am) peg (polyethylene glycol) solution to previous-evening (pm) peg solution for the afternoon colonoscopy. methods: this comparative study compared the am to pm prep for afternoon outpatient colonoscopy. the subjects randomly received peg pm dose ;4 liters of water plus 4 pack peg powder at 6 pm before colonoscopy (250 ml every 15 min) or am ( the same dose solution at 6 am on the day of colonoscopy). the preparation and colonoscopy quality, peg side effects, sleep quality, lesion detection, flush need and suction fluid were compared in these two groups. results: one hundred seven cases received am prep and 102 received pm prep. the colon prep was adequate in 94.4% in am group and in 90.2% cases in pm group (p=0.2). the incidence of adverse events in these two groups was similar. sleep quality and the need for flush was lower in the am group (p=0.004 and p=0.03). the mean volume of suction fluid was higher in the am group (p=0.01). the detected lesions were similar between the two groups. adequate prep was associated with lower flush need in am group (p=0.001). conclusion: am and pm peg solutions were clinically equivalent with cleansing efficacy and side effect and lesion detection. am group was associated with a better sleep quality and less flush need, but more suction fluid.