Chronic myeloid leukemia following colon cancer treatment: A case report and literature review

Background: solid tumors may occur in 3% of the patients with chronic myeloid leukemia (cml). in this paper, we presented a case of cml following treatment of colon cancer. case presentation: a 25 year old man was diagnosed of adenocarcinoma of rectosigmoid treated with fluorouracil-based chemotherapy. following relapse, he received florouracil, oxaliplatin and irinotecan during the next year. then he developed bcr-abl positive cml. with imatinib 400 mg/day, he achieved hematologic response but died because of progressive colon cancer. conclusion: this article emphasizes that there is a possibility for etiologic correlation between cml and chemotherapeutic agents in solid cancers.