The relationship between serum 25-hydroxy vitamin D and blood pressure and quality of life in overweight and obese patients with type 2 diabetes mellitus compared with healthy subjects

Background: vitamin d is one of the known lipoprotein hormones with metabolic properties. we aimed to determine the serum 25-hydroxy vitamin d concentration in overweight/obese subjects with diabetes mellitus type ⅱ (dm ⅱ) in association with systolic and diastolic blood pressure and quality of life compared with healthy participants. methods: the current case-control study was carried out among 80 overweight/obese subjects with dm ⅱ, and 77 healthy subjects matched by sex, age and body mass index (bmi). serum 25- hydroxyvitamin d concentration was measured by elisa method. in order to examine the quality of life, the persian version of sf36 questionnaire was used. results: there was significant difference between diabetic and healthy subjects considering serum 25-hydroxyvitamin d concentration (p=0.012). serum 25-hydroxyvitamin d concentration was inversely correlated with diastolic blood pressure (p=0.02) and positively associated with physical function (p<0.001), social function (p<0.001) and general health (p<0.001) components of quality of life in diabetic subjects and physical health sub-scale (p=0.004) in all participants. conclusion: serum 25-hydroxyvitamin d concentration was significantly lower in diabetic subjects in comparison with healthy controls. there was a significant reverse relationship between serum concentrations of 25-hydroxyvitamin d with diastolic blood pressure and on the other hand, a significant positive relationship with physical function, social function and general health components and physical health subscale of quality of life in participants with dm ⅱ.