Comparison of CD4+ and CD8+ T- lymphocyte in Helicobacter pylori-negative functional dyspepsia

Background: functional dyspepsia (fd) is the most common gastrointestinal disorder with several symptoms such as stomach pain and abdominal bloating. the aim of this study was to investigate and compare cd4+ and cd8+ in the helicobacter pylori-negative functional dyspepsia and control groups. methods: sixty one patients (35 patients with stomach pain and 26 with abdominal bloating), and 30 controls were reviewed based on the quantity of cd4+ and cd8+ t-cells isolated from gastric mucosa biopsy samples. the comparison between variables was analyzed with a chi-square or fisher’s exact test and logistic regression analyses. p<0.05 and odds ratio (or) with a 95% confidence interval demonstrated statistical significance. results: a significant difference was observed between two-group patients and control group based on cd4+ and cd8+ presence, respectively (p=0.003, p=0.008). furthermore, there was a significant difference between stomach pain-patients and control group with regard to cd4 count (p=0.01) and between abdominal bloating-patients and control group with regard to cd8 count (p=0.002). there was a decrease in both cd4+ and cd8+ t-cells in gastric mucosa in patients with fd with a significant reduction in the stomach pain-patients and abdominal bloating-patients in the number of cd4+ and cd8+ t-cells, respectively. conclusion: these results indicated that the role of immunology in the absence of the cd4+ and cd8+ t-cells in the gastric mucosa may have a protective role against fd.