The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency

Background: uterine leiomyomas (fibroids) are the most common benign pelvic tumors in women of reproductive age with an incidence ranging from 5.4% to 77%, also, there is a high prevalence of vit d deficiency in iran and there are the numbers of in vivo and vitro biological studies on the relationship of vitamin d and uterine leiomyomas. the aim of this study was to evaluate the effect of vit d supplementation on the size of uterine leiomyoma in women with vit d deficiency. methods: this double-blind prospective clinical trial was performed on 69 patients with uterine leiomyomas who had vit d deficiency. group a (n=35) was treated with vit d 50,000 iu every 2 weeks for 10 weeks, while group b (n=34) received placebo with same color and shape. finally, the leiomyoma size in both groups was compared (irct: 20160521027998n5). results: after a 10-week intervention, 25-hydroxyvitamin d3 levels were significantly higher in group receiving vitamin d (36.08 vs 16.25 ng/ml). (p<0.001) leiomyomas size in vit d group significantly decreased as compared to placebo group (52.58 vs 61.11 mm, respectively). conclusion: our results showed that administration of vit d3 may reduce the size of leiomyoma. it seems that vitamin d administration is the effective way to treat leiomyoma.