Levels of C-reactive protein, creatine kinase-muscle and aldolase A are suitable biomarkers to detect the risk factors for osteoarthritic disorders: A novel diagnostic protocol

Background: c-reactive protein (crp), creatine kinase-muscle (ck-mm) and aldolase a (aldoa) levels are predicted to be realistic biomarkers of osteoarthritic disorders (oads). the objective of the study was to evaluate the levels of crp, ck-mm, and aldoa and determine their correlations with risk factors such as inflammation, muscle degeneration, and skeletal muscle damage for oads. methods: baseline data from 297 patients, average aged 60.17±7.19 years, suffering with oads for 5.75±1.32 years and 315 participants, average aged 58.96±8.63 years, without oads were collected in this cross-sectional study. separate analyses were performed for the participants with and without oad symptoms confirming with x-ray or mri. blood crp, ck-mm, and aldoa levels were estimated. the receiver operating characteristic (roc) curves, their respective 95% confidence intervals (cis), and significance values were compared between participants with and without oads to identify the risk factors for oads in relation to biomarkers. results: in patients with oads, who exhibited degenerative changes on musculoskeletal joints and risk factors based on the elevated levels of crp, ck-mm, and aldoa having their mean±sd values, 7.22±6.09 mg/l,135.2±78.56 u/l and 8.09±2.15 u/l, respectively. their respective values of areas under the curves (auc) of roc curves were 0.76, 0.68 and 0.91 respectively, of which all exhibited highly significant differences (p<0.0001) compared with the control subjects. conclusion: it is concluded from the results that the elevated levels of studied biomarkers represent the predictive above-mentioned risk factors during oads; therefore, monitoring crp, ck-mm and aldoa levels may be an effective diagnostic method confirming with radiological imaging.