Inflammatory myopathies in a patient with Darier disease, a possible association

Background: darier disease (dd) is an autosomal dominant genetic disorder which develops from a mutation in the atp2a2 gene. inflammatory myopathies (im) are the largest group of potentially treatable myopathies. in this case, we report development of im in a patient with dd for the second time in the literature.case presentation: the patient is a 59-year-old female, a known case of dd, who developed proximal muscle weakness 2 weeks prior to admission. elevated muscle-enzymes, as well as typical electromyographic and radiologic confirmed the diagnosis of im. conclusions: abnormalities in intracellular calcium homeostasis may explain the association between dm and dd, therefore it is noteworthy to keep this association in mind and conduct more research regarding this issue.