Effect of a 12-week submaximal swimming training in rats exposed to tobacco- derived nitrosamine ketone

Background: tobacco contains carcinogens such as nnk (nicotine-derived nitrosamine ketone) that makes induction of lung cancer by changing the stimulation of il-10 expression. the aim of this study was to investigate changes in resting levels of il-10 in lung tissues of rats exposed to nnk after a 12-week aerobic submaximal swimming training. methods: for this purpose, 46 wistar rats were randomly divided into five groups consisting training, training + nnk, nnk, saline and control. nnk-induced groups received nnk subcutaneously one day per week at a rate of 12/5 mg per kg body weight and the training groups performed submaximal swimming training for 12 weeks. the levels of il-10 in homogenized lung tissue were measured by elisa.results: findings indicated that a period of swimming training increased the il-10 levels significantly in lung tissue of training group when compared to control (p=0.00) and nnk groups (p=0.00). also, a significant increase of il-10 level was observed in exercise + nnk group when compared to nnk group (p.0/02). furthermore, it was observed that il-10 levels of nnk group had a significant decrease when compared to training group (p=0/00), training + nnk group (p.0/02), but had insignificant increase when compared to saline group (p.0/85). conclusions: generally, it could be confirmed that regular submaximal aerobic training plays an important role in the inhibition of the effects of lung inflammation induced by nnk via increasing il-10 activity.