Anti-coagulation therapy following coronary endarterectomy in patient with coronary artery bypass graft

Background: since there is a lack of research on postoperative anticoagulation protocol in patients undergoing coronary artery bypass graft (cabg) / coronary endarterectomy (ce), we recommend a new protocol for anticoagulation in these patients. methods: in this double-blind randomized clinical trial study, 52 patients undergoing cabg / ce entered the study and were divided into two groups. in group 1, the patients were given warfarin(international normalized ratio (inr) between 2 -3) together with 80 mg aspirin daily for 3 months. in group 2, the patients were given 75 mg plavix daily together with 80 mg aspirin daily for 3 months. we evaluated patients with electrocardiography, echocardiography and checking ceratin phosphokinase mb and troponin i in the several stages. the data were analysed spss version18 software. results: there was no significant difference between pre and post-operative ejection fraction in patients with plavix (p=0.21) and warfarin (p=0.316) regimen. however, wall mrotion score was significantly better in clopidogrel – aspirin patients in late (3 months) post operation (p<0.001). conclusions: since warfarin has serious hemorrhagic complications and requires closed monitoring of serum drug activity by serial inr checking, it is recommended that clopidogrel – aspirin can be the preferred alternative anticoagulation therapy in cabg / ce patients.