Both immune hormone IL-10 and parathormone tend to increase in serum of old osteoporotic people independently of 1,25 dihydroxy vitamin D3

Background: in this study,we determined the serum levels of il-17a and il-10 in context with 1,2 dihydroxy vitamin d3,parathormone and ca2+/pi ions to investigate their pathological or protective roles respectively in bone metabolism. methods: the bone mineral density (bmd) was determined for 1203 participants using energy x-ray absorptiometry. subjects with a history of diseases and using bone metabolism medications were excluded and finally serum il-10 was measured in 82 osteoporotic and 74 healthy individuals (mean age ±sd of 71.04±6.9 and 68.58±6.9 respectively). also,the serum level of il-17a was assessed in 42 osteoporotic and 39 non-osteoporotic subjects (mean age±sd of 69.40±6.7 and 70.77±7.1,respectively). serum levels of 1,25-dihydroxyvitamin d3,ca2+/pi ions and parathormone were extracted from ahap cohort data bank. results: il-17a was detectable in 7.42(16.67%) osteoporotic subjects and 3.39(7.69%) normal subjects. surprisingly,patient subjects exhibited a higher level of serum il-10 than normal subjects (p=0.023). we found that the serum parathormone levels tend to increase in patient group (p=0.003) in comparison to normal control with no correlation with il-10 levels. there was no significant difference between the two groups in the serum levels of 1,25-dihydroxyvitamin d3,ca2+and pi ions. conclusion: in reaction to chronic inflammation old osteoporotic patients independent of 1,25 dihydroxy vitamin d3 may produce a higher level of il-10 to dampen production of inflammatory cytokines including il-17a which in turn leads to speeding up parathormone production ultimately reaching a new homeostasis status in bone metabolism with normal serum ca2+ /pi ions.