Salivary Oxidant/ Antioxidant Status and Hematological Parameters in Patients With Recurrent Aphthous Stomatitis

Background: recurrent aphthous stomatitis (ras) is the most common inflammatory ulcerative condition of oral cavity. the aim of this study was to compare the levels of the salivary malondialdehyde (mda) and total antioxidant capacity (tac) and blood parameter in ras versus healthy controls. methods: this case-control study consisted of 28 patients with ras and 28 age and sex-matched control without ras. cell blood count,serum iron and total iron binding capacity and ferritin were measured using standard laboratory kit with elisa method. in statistical analysis,student's t-test,mann whitney and pearson's correlation test were used for data analyses. results: salivary mda level was significantly higher (p<0.001) and tac level was significantly lower (p<0.042) in ras as compared with the control group. furthermore,serum ferritin level was significantly higher in ras patients (p<0.008). conclusion: these findings show alteration of mda,tac and serum ferritin that in patients with ras,indicate the presence of an inflammatory process. these variations may have a contribution in the development or persistence of ras.