effect of a period of intense functional training on il-10, dectin-1, and il-1ra in prediabetic obese women

Background: obesity and prediabetes are associated with chronic low-grade inflammation, and macrophage-related markers such as il-10, dectin-1, and il-1ra play a key role in modulating inflammatory responses. the purpose of this study was to investigate the effect of a period of high-intensity functional training (hift) on il-10, dectin-1, and il-1ra in prediabetic obese women to assess the impact of this exercise modality on m2 macrophage markers.methods: thirty eligible female volunteers aged 35-40 years were selected and homogeneously divided into two groups: 1) control (n=15) and 2) training (n=15). the training group underwent a 16-week hift program based on crossfit protocols, incorporating squats, deadlifts, barbell/dumbbell exercises, kettlebell swings, and aerobic/weight-bearing movements in a workout of the day format (60 min/session). the control group maintained their daily routines without structured exercise. serum levels of dectin-1, il-10, and il-1ra were measured via elisa. descriptive statistics (mean, standard deviation) were used for data analysis.results: after 16 weeks, hift significantly reduced dectin-1 (p = 0.048) and increased il-10 (p < 0.0001) and il-1ra (p < 0.0001) levels in prediabetic obese women.conclusion: these findings suggest that 16 weeks of hift may enhance anti-inflammatory markers (il-10, il-1ra) and modulate dectin-1, potentially mitigating obesity-related inflammatory complications in prediabetic women.