investigation of the simultaneous effect of resistance training and atorvastatin in improving nonalcoholic fatty liver disease in wistar rats fed high high-fat/fructose diet

Background: non-alcoholic fatty liver disease (nafld), a highly prevalent and chronic liver disease, is characterized by a diverse range of conditions that span across a broad spectrum. engaging in consistent physical activity has proven to be a successful method in effectively managing nafld, as it has demonstrated the ability to enhance crucial elements implicated in the development of the condition.methods: twenty-one male wistar rats were divided into three groups: 1. nafld, 2. nafld + resistance training (rt), and 3. nafld + rt + atorvastatin (ato). the groups received high-fat/fructose diet (hffd) to induce nafld and it was confirmed through evaluation of histopathological analysis (h&e staining) and measurement of aminotransferase enzymes. ato was administrated at a dose of 2 mg/kg/day. the interventions were carried out over eight weeks.results: triglyceride (tg), alanine transaminase (alt), and aspartate transaminase (ast) were significantly reduced in the nafld + rt + ato group. additionally, low-density lipoprotein (ldl) levels were lower in nafld + rt group than nafld + rt + ato group. alkaline phosphatase (alp) was reduced in both nafld + rt and nafld + rt + ato groups compared to nafld. there was no significant difference in weight between the groups except the first, second, and fourth weeks.conclusion: resistance training in combination with the administration of ato can be deemed as an efficacious and supplementary strategy to effectively control and address nafld.