evaluation of blood glucose-lowering activity of aqueous extract of bark of ficus lacor buch ham in alloxan-induced diabetes in new zealand white rabbits

Background: although the anti-diabetic effects of various ficus species have been investigated in animal models, research on the blood glucose-lowering potentials of ficus lacor buch ham bark remains sparse. this study evaluated the blood glucose-lowering potentials of an aqueous extract derived from ficus labor bark in a diabetic rabbit model.methods: diabetes was induced in rabbits through intravenous administration of alloxan monohydrate (120 mg/kg). 36 rabbits were divided into six groups, each consisting of six animals. control groups included a non-diabetic control (distilled water) and a diabetic control (distilled water). two experimental groups received ficus lacor extract at doses of 100 mg/kg (low-dose) and 200 mg/kg (high-dose) orally for six weeks. metformin was used as an active control. a non-diabetic group (extract control) was also administered ficus lacor extract at 200 mg/kg. fasting blood sugar (fbs) and post-prandial blood sugar (pp2bs) levels were measured weekly over the 6 weeks. the percentage reduction in blood glucose levels was calculated and compared for each group.results: the administration of both low-dose and high-dose ficus lacor extracts resulted in significant reductions in fbs and pp2bs levels in diabetic rabbits. after six weeks, the low-dose extract group exhibited an average reduction of 38.3% in fbs and 40.5% in pp2bs, whereas the high-dose extract group showed average reductions of 35.3% in fbs and 36.3% in pp2bs.conclusion: the aqueous extract of ficus lacor bark demonstrates substantial glucose-lowering activity, indicating its potential utility as a therapeutic agent in diabetes management.