effect of high-intensity interval training on omentin-1 serum levels, gene expression, and insulin resistance in type 2 diabetic rats

Background: omentin-1 plays an important role in insulin function. despite numerous studies, the effect of interval training on this adipokine is still vague. this study aimed to elucidate the effect of high-intensity interval training (hiit) on serum glucose, insulin, insulin resistance (ir), omentin-1 serum levels, and gene expression in the visceral adipose tissue in type 2 diabetic (t2d) rats.methods: in an experimental study, 20 male rats (8-10 weeks, weight: 250-270 g) were randomly divided into 2 groups: diabetic control (n=10) and diabetic training (n=10). the training protocol was 30 minutes of hiit (1-min run, 2-min rest) performed 5 days a week for 4 weeks. fasting blood glucose, insulin resistance, omentin-1 serum level, and gene expression were measured in the visceral fat 48 hours after the last exercise for both groups.results: the hiit resulted in lower serum glucose and insulin resistance (p = 0.001), higher serum omentin-1 levels (p = 0.001), and higher visceral fat gene expression (p = 0.004) in the training group compared to the control group.conclusion: lower serum glucose and insulin resistance and higher omentin-1 serum levels and gene expression in the training group can prove the effectiveness of hiit training in t2d, although further research is required.