vascular senescence and resistance exercise training: focus on circulating endothelial cell-derived microrna-92a and endothelin-1

Background and objectives: vascular senescence refers to specific aging-associated changes in the endothelial cells. the purpose of this study was to investigate effects of 12 weeks of resistance training with elastic bands on circulating endothelial cell-derived microrna-92a and endothelin-1 (et-1) in elderly women with osteosarcopenic obesity (oso).methods: in the present randomized clinical trial, 48 elderly women with oso were randomly divided into a control group (n=22) and an experimental group (n=26). the subjects in the intervention group performed 12 weeks of resistance training with elastic bands three times a week. the participants became familiar with targeted number of repetitions and omni-resistance exercise scale to control exercise intensity.results: the mean age, body fat percentage, body mass index (bmi), and bone mineral density t-score for the hip and l1-l4 lumbar spine of the subjects were 64.13±3.68 years, 45.4%±6.56, 33.1±3.71 kg/m2, and -1.86±1.42, respectively. after the 12-week resistance training, we observed a significant decrease in serum level of mir-92a in the experimental group compared to the control group (p=0.03). however, there was no significant difference between the study groups in terms of body weight, bmi, body fat percentage, total cholesterol, and et-1 (p≥0.05). conclusion: the 12-week resistance training program seems to modulate and decrease serum mir-92a expression in elderly women with oso. the lack of a significant change in bmi, body fat percentage, and et-1 levels following the exercise training might be due to the type and intensity of the exercises.