Effect of Eight Weeks Aerobic and Combined Training on Serum Levels of Sirtuin 1 and Pgc-1α in Coronary Artery Bypass Graft Patients

Background and objectives: sirtuin-1 (sirt1) is a conserved a nad+-dependent protein deacetylase essential for cellular metabolism and defence against oxidative stress and endothelial dysfunction. this study aimed to compare effects of 8 weeks of aerobic and combined training on serum level of sirt1 and pgc1-α in coronary artery bypass graft patients. methods: in this semi-experimental study, 45 non-active men (mean age 47.4 ± 3.3 years) who had undergone coronary artery bypass graft surgery were randomly divided into three groups: aerobic training, combined resistance and aerobic training and control. trainings were performed at 80% of maximum heart rate, three sessions a week for 8 weeks. blood samples were collected 24 hours before the first exercise session and 48 hours after the last training session. t-test and one-way analysis of variance were used for assessment of within-group and between-group differences, respectively. p-values less than 0.05 were considered as statistically significant. results: the 8-week aerobic and combined training increased serum levels of sirt1 and pgc-1α compared with the control group, and significantly decreased the weight of subjects (p=0.001). there was no significant difference in serum levels of sirt1 and pgc-1α between the two training groups (p≥0.05). conclusion: both combined and aerobic training significantly improve the sirt1 and pgc-1α levels in coronary artery bypass graft patients.