Association of HDL/TG Ratio as an Insulin Resistance Marker with Various Levels of Fasting Blood Glucose

Background and objective: the association of triglyceride/high density lipoprotein-cholesterol (tg/hdl-c) ratio with fasting serum insulin, which is an alternative method of insulin resistance (ir) measurement, is well-recognized. thus, the measurement of tg/hdl-c ratio is useful to determine both ir and dyslipidemia, which itself is a characteristic of individuals with ir. therefore, this study aimed to investigate the relationship between tg/hdl ratio as an indicator of ir, with different fasting blood glucose levels. methods: this case-control study was performed on 343 volunteers with no history of diabetes or use of blood glucose-lowering medications and fasting blood sugar (fbs) levels of less than 126 mg/dl. after sampling, the subjects were divided into three groups based on their fbs level. first group included healthy subjects with fbs of less than 100 mg/dl. second group consisted of subjects with impaired fasting glucose (ifg) and fbs of 110-100 mg/dl and a third group including those with impaired glucose tolerance (igt) and fbs of 110-125 mg/dl. results: the amount of tg/hdl-c ratio was 3.8 ± 2.8, 4.0 ± 2.1 and 5.4 ± 3.8 for the healthy group, individuals with ifg and igt, respectively. the tg/hdl index was significantly different among the tested groups with no significant difference between healthy subjects and subjects with ifg. moreover, there was a statistically significant difference between the igt and ifg groups with healthy individuals. conclusion: considering the significant increase of the tg/hdl ratio in groups with impaired glucose, using this index can be helpful in evaluation of glycemic disorder.