antibacterial effect of silver nanoparticles along with l-arginine against p. aeruginosa

Background and objectives: nowadays, the prevalence of multidrug-resistant pathogens such as pseudomonas aeruginosa is increasing worldwide. many studies have been seeking new treatment strategies to treat infections caused by these microorganisms. silver nanoparticles (agnps) along with l-arginine have significant antimicrobial effects and could be used as alternatives for ineffective drugs. methods: in this study, the antibacterial activity of agnps, l-arginine and various concentrations of agnps along with l-arginine (12.5 and 25 mg/ml) were investigated against p. aeruginosa pao1 using the broth macrodilution method. results: minimum inhibitory concentration of agnps, l-arginine and agnps combined with 25 and 12.5 mg/ml l-arginine was 15.6 μg/ml, 25 mg/ml, 1.9 μg/ml and 3.9 μg/ml, respectively. minimum bactericidal concentration of agnps, l-arginine and agnps combined with 25 and 12.5 mg/ml l-arginine was 31.2 μg/ml, 50 mg/ml, 3.9 μg/ml and 7.8 μg/ml, respectively. conclusion: our study suggests that agnps along with l-arginine can be used as an alternative antibacterial agent against p. aeruginosa, and might be useful for treatment of wound infections.