effect of vigorous aerobic exercise on serum levels of sirt1, fgf21 and fetuin a in women with type ii diabetes

Background and objectives: sirtuin (sirt), fibroblast growth factor21 (fgf21) and fetuin a are proteins that cause a wide range of metabolic disorders such as type 2 diabetes mellitus (t2dm). on the other hand, regular physical activity is known to play a key role in prevention and management of t2dm. thus, this study investigated the effect of vigorous aerobic exercise on serum levels of metabolic parameters including sirt1, fgf21 and fetuin a in women with t2dm. methods: the study was performed on 28 randomly selected women with t2dm who were divided into an exercise group and a control group. the training intervention consisted eight weeks of vigorous aerobic exercise (three times a week at 70-80% of maximum heart rate). the serum levels of sirt1, fgf21 and fetuin a were evaluated before the first session and 48 hours after the last session. paired sample t-test and independent t-test were used to analyze within and between group differences, respectively. all statistical analyses were performed in spss (version 19) at significance of 0.05. results: the eight-week aerobic training caused a significant reduction in body weight, body mass index, insulin resistance, low-density lipoprotein, fasting blood sugar, triglycerides and fetuin a of women with t2dm. in addition, it caused a significant increase in sirt1 and fgf21 levels. there was no significant difference in the level of high-density lipoprotein and cholesterol between the two groups. conclusion: as a non-pharmacological therapy, regular aerobic exercise might improve the metabolic parameters, sirt1, fgf21, and fetuin a in women with t2dm.