Pdcd1 Single Nucleotide Polymorphisms in Iranian Patients With Juvenile Idiopathic Arthritis

Juvenile idiopathic arthritis (jia) is a clinically heterogeneous cluster of complex diseases, in which both the genetic and environmental factors seem to play a role in the development of the disease. the current study aims to assess the association of programmed cell death 1 (pdcd1, also called pd-1) gene variants with jia vulnerability in iranian population. in this case-control association study, we investigated a group of 50 iranian patients with jia in comparison with 202 healthy controls and evaluated the frequency of alleles, genotypes, and haplotypes of pdcd1 single-nucleotide polymorphisms (snps), comprising pd-1.1 g/a, pd-1.3 g/a and pd-1.9 c/t, using pcr-rflp method. both the allelic and genotype frequencies of pd-1.1, pd-1.3 and pd-1.9 were similar in two groups of patients and controls. moreover, no significant difference was observed between the two groups of patients and controls for ggc (pd-1.1 g, pd-1.3 g, pd-1.9 c), gac (pd-1.1 g, pd-1.3 a, pd-1.9 c), and agt (pd-1.1 a, pd-1.3 g, pd-1.9 t) haplotypes. our results did not show any association between pdcd1 snps and the development of jia in iranian population.