Adult onset still’s disease with different antibodies: A case report and a review of literature

Adult-onset still’s disease (aosd) is a rare systemic inflammatory disorder of unknown etiology. there is not currently any specific serological markers for aosd,and diagnosis still relying on the exclusion of other likely diagnoses. yamaguchi’s criteria are used as a diagnostic criterion which contains negative serologic markers for other collagen vascular diseases including systemic lupus erythematosus and rheumatoid arthritis. here we report a 28-year-old woman with arthralgia,fever,rash,leukocytosis,lymphadenopathy,sore throat,abnormal liver function and negative rheumatoid factor and ana but seropositive for anti-ccp,anti-dsdna,and c-anca. it seems that despite aosd is considered as a seronegativedisorder; it should be remembered in patients with compatible findings who are seropositive. © 2016 tehran university of medical sciences. all rights reserved.