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protective effects of lithium on sumatriptan-induced memory impairment in mice
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نویسنده
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nikoui vahid ,javadi-paydar mehrak ,salehi mahtab ,behestani selda ,dehpour ahmad reza
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منبع
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acta medica iranica - 2016 - دوره : 54 - شماره : 4 - صفحه:226 -232
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چکیده
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lithium is a drug used for the treatment of bipolar disorder. it has several mechanisms of action, and recently it is shown that lithium can antagonize the 5-ht1b/1d serotonin receptors. sumatriptan is a 5-ht1b/1d receptor agonist used for the treatment of cluster headaches and migraine which might cause memory impairment as a potential side effect. in this study, effects of lithium on sumatriptan-induced memory impairment have been determined in a two-trial recognition y-maze and passive avoidance tests. male mice weighing 25-30 g were divided into several groups randomly. in y-maze test, effects of lithium (1,5,10,20,40,80 mg/kg) and sumatriptan (1,5,10 mg/kg) were assessed on memory acquisition, then lithium (0.1,1,10 mg/kg) and sumatriptan (1,10 mg/kg) were studied in passive avoidance test. effects of lithium (1mg/kg) on sumatriptan (10 mg/kg)-induced memory impairment were studied in both of tests. the present study demonstrated that sumatriptan impaired memory in y-maze and passive avoidance tests (p<0.05, p<0.01, respectively). lithium did not show any significant effect on memory function compared to saline-treated control group in both tests (p>0.05), but significantly reversed sumatriptan-induced memory impairment in y-maze and passive avoidance tests (p<0.001, p<0.05, respectively). it is concluded that lithium reverses the sumatriptan-induced memory impairment probably through 5-ht1b/1d receptors antagonism. |
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کلیدواژه
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lithium ,sumatriptan ,5-ht1b/1d ,spatial recognition memory ,mice
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آدرس
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experimental medicine research center, tehran university of medical sciences, tehran, iran. and razi drug research center, iran university of medical sciences, tehran, iran., Iran, Islamic Republic of, tehran university of medical sciences tums, ایران, tehran university of medical sciences tums, ایران, tehran university of medical sciences tums, ایران, experimental medicine research center, tehran university of medical sciences, tehran, iran. and department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran., Iran, Islamic Republic of
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پست الکترونیکی
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dehpour@yahoo.com
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Authors
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