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association of dc-sign and dc-signr repeat regions with susceptibility to pulmonary tuberculosis in zahedan, southeastern iran
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نویسنده
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naderi mohammad ,hashemi mohammad ,soroush navid ,amininia shadi ,taheri mohsen
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منبع
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acta medica iranica - 2016 - دوره : 54 - شماره : 5 - صفحه:308 -312
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چکیده
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there are conflicting results concerning dc-sign and dc-signr vntr polymorphisms. the present study aimed to evaluate the possible association between dc-sign as well as dc-signr vntr polymorphisms and pulmonary tuberculosis (ptb) in a sample of iranian population. this case-control study was done on 171 ptb and 161 healthy subjects. the variants were detected by polymerase chain reaction (pcr). dc-signr vntr genotypes in cases were 12.7% for 5/5, 2.4% for 6/5, 32.7% for 7/7, 38.2% for 7/5, 5.5% for 7/6, 1.2% for /5, 0.6% for 9/6, 6.7% for 9/7 in ptb patients and 19.7% for 5/5, 2.0% for 6/5, 31.6% for 7/7, 37.5% for 7/5, 5.7% for 7/6, 0.0% for 9/5, 0.7% for 9/6, 2.6% for 9/7 in controls. the findings showed no significant association between dc-signr vntr polymorphism and ptb. all subjects in cases and controls were 7/7 genotype regarding dc-sign vntr polymorphism. our data propose that dc-signr vntr, as well as dc-sign vntr, were not associated with the risk of ptb in a sample of iranian population. |
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کلیدواژه
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tuberculosis ,dc-sign ,dc-signr ,vntr ,polymorphism
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آدرس
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infectious diseases and tropical medicine research center, zahedan university of medical sciences, zahedan, iran., Iran, Islamic Republic of, cellular and molecular research center, zahedan university of medical sciences, zahedan, iran. and department of clinical biochemistry, school of medicine, zahedan university of medical sciences, zahedan, iran., Iran, Islamic Republic of, infectious diseases and tropical medicine research center, zahedan university of medical sciences, zahedan, iran., Iran, Islamic Republic of, department of clinical biochemistry, school of medicine, zahedan university of medical sciences, zahedan, iran., Iran, Islamic Republic of, genetics of non-communicable diseases research center, zahedan university of medical sciences, zahedan, iran., Iran, Islamic Republic of
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پست الکترونیکی
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hashemim@zaums.ac.ir
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Authors
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