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evaluation of nanocarrier targeted drug delivery of capecitabine-pamam dendrimer complex in a mice colorectal cancer model
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نویسنده
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nabavizadeh fatemeh ,fanaei hafseh ,imani alireza ,vahedian jalal ,asadi amoli fahimeh ,ghorbi jamal ,sohanaki hamid ,mohammadi seyed mehdi ,golchoobian ravieh
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منبع
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acta medica iranica - 2016 - دوره : 54 - شماره : 8 - صفحه:485 -493
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چکیده
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capecitabine, an effective anticancer drug in colorectal cancer chemotherapy, may create adverse side effects on healthy tissues. in the present study, we first induced colon adenocarcinoma with azoxymethane, a carcinogen agent, and then investigated the potentiality of polyamidoamine (pamam) dendrimer to improve capecitabine therapeutic index and decrease its adverse side effects on healthy tissues like liver and bone marrow. other variables such as nanoparticle concentrations have also been investigated. drug loading concentration (dlc) and encapsulation efficiency (ee) were calculated for capecitabine/dendrimer complex. experimental results showed an increase in dlc percentage resulted from elevated capecitabine/dendrimer ratio. capecitabine/dendrimer complex could reduce tumor size and adverse side effects in comparison with free capecitabine form. |
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کلیدواژه
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colorectal cancer ,azoxymethane ,capecitabine ,polyamidoamine (pamam) dendrimer
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آدرس
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departement of physiology, school of medicine, tehran university of medical sciences, tehran, iran., Iran, Islamic Republic of, departement of physiology, school of medicine, tehran university of medical sciences, tehran, iran., Iran, Islamic Republic of, departement of physiology, school of medicine, tehran university of medical sciences, tehran, iran., Iran, Islamic Republic of, department of surgery, firuzgar hospital, iran university of medical sciences, tehran, iran., Iran, Islamic Republic of, departement of physiology, school of medicine, tehran university of medical sciences, tehran, iran., Iran, Islamic Republic of, department of bio-medical engineering and medical physics, shahid beheshti university of medical sciences, tehran, iran., Iran, Islamic Republic of, departement of physiology, school of medicine, tehran university of medical sciences, tehran, iran., Iran, Islamic Republic of, departement of physiology, school of medicine, tehran university of medical sciences, tehran, iran., Iran, Islamic Republic of, departement of physiology, school of medicine, tehran university of medical sciences, tehran, iran., Iran, Islamic Republic of
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پست الکترونیکی
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nabavizadeh@tums.ac.ir
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Authors
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