Prevalence of Celiac Disease in Patients With Turner’S Syndrome

Celiac disease (cd) has been reported in association with genetic disorders such as down’ssyndrome and turner’s syndrome (ts). this study was undertaken to assess the prevalence of cdamong a group of patients with ts. forty eight girls with ts and a control group composed by 48healthy unrelated girls were screened for cd by iga antiendomysial antibody (iga-ema). total iga ofserum was measured in all of the patients and controls and ema was measured in subjects who hadnormal range of iga. endoscopy and biopsy of duodenum was performed for ema positive patientsand pathologic evaluation was done according to marsh’s classification. total iga of serum in all of thesubjects was in normal range. two subjects, both with ts, were ema positive, resulting in a prevalenceof 4.1% in ts. duodenal biopsy was performed in these patients and histologic changes of sampleswere classified as grade ii in one and grade ii b in another one. results of this study are compatiblewith previous observations placing girls with ts at higher risk for cd relative to general population andjustifying screening of cd in patients with ts.