Dyslipidemia in Type 2 Diabetes Mellitus: More Atherogenic Lipid Profile in Women

Previous studies have shown that diabetes mellitus (dm) increases the risk of cardiovasculardisease in women to a greater extent than in men. it seems that dm may alter lipid profiles moreadversely in women compared to men. in this study we evaluated serum lipoprotein differences in type2 diabetic men and women. the study included 350 type 2 diabetic patients (100 men and 250 women),aged 19-82 years. demographic data were and biochemistry tests including serum lipoproteins weremeasured. there was no difference between men and women with respect to duration of dm and typeof treatment. body mass index (bmi), systolic and diastolic blood pressures were significantly higherin women than age matched men. women also had significantly higher plasma levels of totalcholesterol (233.7 vs. 190.3 mg/dl, p < 0.001), triglycerides (219.7 vs. 180.6 mg/dl, p < 0.05), lowdensitylipoprotein cholesterol (ldl-c) (141.2 vs. 116.1 mg/dl, p < 0.001), high-density lipoproteincholesterol (hdl-c) (47.1 vs. 39.4 mg/dl, p < 0.001), non-hdl cholesterol (186.1 vs. 150.8 mg/dl, p <0.05), lp(a) (50.7 vs. 38.2 mg/dl, p < 0.05) and apo-b (117.6 vs. 101.2 mg/dl, p < 0.001). all types ofdyslipidemia were significantly more prevalent in females. women had higher plasma levels of hdl-ccompared to men. higher prevalence of hypertriglyceridemia in females was due to their higher bmi,and sex was not an independent risk factor for hypertriglyceridemia. type 2 diabetic women areexposed more profoundly to risk factors including atherogenic dyslipidemia and higher bmi, systolicand diastolic blood pressures compared to men.