PREVALENCE OF MICROALBUMINURIA IN CHILDREN AND ADOLESCENTS WITH DIABETES MELLITUS TYPE I

Persistent microalbuminuria is predictive of nephropathy in patients with type i diabetesmellitus (dm) and has led to the development of screening programs and intervention studies. wereport a longitudinal evaluation of urinary albumin excretion in 118 children with type i dm, attendinga single clinic over a period of seven years. collected blood and urine samples were analyzed forglycated hemoglobin (hb a1c), cholesterol, triglyceride (tg), creatinine and for 12 h urinary albuminand creatinine concentrations. blood pressures were recorded and clinical data collected. twenty– three(19.5%) children had persistent microalbuminuria (urine albumin 30-300 mg/24 h) on at least threeconsecutive occasions. factors associated with microalbuminuria in diabetic children included longerduration of dm, higher mean age, higher mean hb a1c, higher mean arterial blood pressure and highercholesterol and tg levels (p < 0.001). significantly more girls than boys and more pubertal and postpubertal patients had microalbuminuria but one patient developed microalbuminuria under the age of 11years. in conclusion, microalbuminuria may appear as early as the prepubertal period, suggesting thatmetabolic control of dm is an important factor of diabetic nephropathy.