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   Elevated serum levels of pregnancy-associated plasma protein-a in type 2 diabetics compared to healthy controls: Associations with subclinical atherosclerosis parameters  
   
نویسنده heidari b. ,fotouhi a. ,sharifi f. ,mohammad k. ,pajouhi m. ,paydary k. ,fakhrzadeh h.
منبع acta medica iranica - 2015 - دوره : 53 - شماره : 7 - صفحه:395 -402
چکیده    Type 2 diabetes mellitus is associated with increased inflammation and accelerated atherosclerosis. the association of the pro-inflammatory and potentially pro-atherosclerotic molecule,pregnancy associated plasma protein-a (papp-a) with diabetes and vascular diseases remains to be further established. a total of 107 patients with type 2 diabetes and 101 healthy controls participated in this study. serum levels of papp-a was measured by enzyme-linked immunosorbent assay (elisa). we also evaluated the lipid profile,aortic augmentation index,coronary calcium score,ankle brachial index,flow mediated dilation,and carotid intima media thickness. serum level of papp-a was significantly higher in patients with diabetes compared to controls (p<0.001). in the multivariable regression analysis,papp-a was positively correlated with diabetes (p<0.001),aortic augmentation index (p=0.021) and was negatively associated with coronary calcification (p=0.050). in conclusion,serum levels of papp-a were significantly higher in diabetics compared to healthy controls and correlated with aortic augmentation index and coronary calcification. our study results suggest that papp-a can be a marker of subclinical atherosclerosis in patients with diabetes. © 2015 tehran university of medical sciences. all rights reserved.
کلیدواژه Augmentation index; Coronary calcium score; Diabetes mellitus; Pregnancy associated plasma protein-A; Subclinical atherosclerosis
آدرس elderly health research center,endocrinology and metabolism population sciences institute,tehran university of medical sciences,tehran,iran,endocrinology and metabolism research center,valiasr hospital,school of medicine,tehran university of medical sciences, ایران, department of epidemiology and biostatistics,school of public health,tehran university of medical sciences, ایران, elderly health research center,endocrinology and metabolism population sciences institute,tehran university of medical sciences, ایران, department of epidemiology and biostatistics,school of public health,tehran university of medical sciences, ایران, endocrinology and metabolism research center,endocrinology and metabolism clinical sciences institute,tehran university of medical sciences, ایران, iranian research center for hiv/aids (ircha),iranian institute for reduction of high-risk behaviors,tehran university of medical sciences, ایران, elderly health research center,endocrinology and metabolism population sciences institute,tehran university of medical sciences, ایران
 
     
   
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