Comparison of serum LP-PLA2 level and some nutritional factors between well-controlled and poorly-controlled diabetic patients

Lipoprotein-associated phospholipase a2 (lp-pla2) is produced by inflammatory cells,bound to ldl and other lipoproteins,and hydrolyzes oxidized phospholipids in ldl. type 2 diabetes is the most common form of diabetes some investigations show the association of lipoprotein-associated phospholipase a2 mass and activity with the incidence of cardiovascular disease (cvd) in populations with high prevalences of insulin resistance and diabetes. this study is a cross-sectional descriptive and analytic study on 80 individuals with diabetes referring to the tehran diabetes association. patients divided into two groups (well-controlled and poorly controlled) based on their hba1c. personal information,anthropometric assessments (including height,weight,waist circumference and hip circumference) and semi-quantitative 147 items ffq was used and vein blood samples were taken. after plasma separation,blood sample used for fbs,hba1c and lp-pla2 measurement. the independent sample t test was used for comparing means. data analyses showed a significant difference between weight and whr (waist to hip ratio) means in two studied groups,also there was a statistically significant difference in food intake (energy,carbohydrate,protein,micronutrients percent and some of the micronutrients). fbs,hba1c and lp-pla2 means showed statistically significant difference (p<0/001) between two groups. this study showed lp-pla2 is elevated in poorly-controlled patients compared to well-controlled diabetic patients,which may suggest some nutritional factors contributing to the regulation of this enzyme. © 2015 tehran university of medical sciences. all rights reserved.