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FAMILIAL DEFECTIVE APOLIPORROTEIN B 100: FREQUENCY OF R3500Q MUTATION OF APOLIPOROTEIN B GE E IN IRANIAN HYPERCHOLESTEROLEMIC PATIENTS
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نویسنده
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F'ard-Esfahan P ,Mohammadi-Torbati P ,Khatami S ,Zeinal S ,Taghikhani M ,Allahyari M
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منبع
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acta medica iranica - 2005 - دوره : 43 - شماره : 3 - صفحه:193 -196
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چکیده
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Familial defective apolipoprotein (apo) b 100 (fob) causes early-onset coronary heartdiseases (cho). it is produced by r3500q mutation of the apob gene resulting in decreased binding ofldl to ldl receptor. we screened the apo b gene for r3500q mutation in 130 hypercholesterolemicpatients, among whom 30 patients met criteria of familial hypercholesterolemia (fh). the prevalence ofr3500q allele in this patient population was 0%. to obtain better estimation of mutation frequency, abroad survey is needed.
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کلیدواژه
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Familial defective apolipoprotein ,familial hypercholesterolemia
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آدرس
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Pasteur Iinstitute of Iran, ایران, shahid beheshti university of medical sciences, ایران, Pasteur Iinstitute of Iran, ایران, Pasteur Iinstitute of Iran, ایران, tarbiat modares university, ایران, Pasteur Iinstitute of Iran, ایران
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پست الکترونیکی
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fard_esfahani@pasteur.ac.ir
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Authors
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