THE EFFECTS OF ANODAL IONTOPHORESIS OF EPINEPHRINE ON NEUROMUSCULAR RESPONSES IN HEALTHY MEN AND PATIENTS WITH MYASTHENIA GRAVIS

Iontophoresis of epinephrine for assessment of neuromuscular junction response is a newtechnique that can improve diagnose of neuromuscular dysfunction. the purpose of this study was toinvestigate the effects of iontophoresis of epinephrine on neuromuscular junction response. iontophoresis ofepinephrine solution (1 mg/ml), sodium chloride, calcium gluconate, epinephrine with sodium chloride anddistilled water was applied in five groups of healthy men and 7 patients with myasthenia gravis (mg).amplitude, depolarization, repolarization and recovery times and slops of con1pound muscle actionpotential (cmap) were measured. also low repetition stimulus tests were applied before and afteriontophoresis of epinephrine. following results were obtained: 1) iontophoresis of sodium ion increaseddepolarization time, and iontophoresis of sodium and calcium ions increased recovery and duration times ofcmap, 2) slope of depolarization and recovery were reduced by iontophoresis of active ions, 3)iontophoresis of epinephrine increased slope of recovery or na-k transport at 10 and 15 minutes afteriontophoresis, 4) iontophoresis of epinephrine in patients with mg reduced amplitudes of all cmaps andpercentage of decrement between first and fifth signal increased at low frequency stimulus test, and 5)iontophoresis of epinephrine in normal group increased percentage of amplitude increment between firstand fifth signal in low frequency stimulation test. neuromuscular responses in patients with mg incolnparison to normal men are sensitive to iontophoresis of epinephrine and demonstrate significantdecrement findings to low repetition stimulus tests. iontophoresis of epinephrine with rns tests can beuseful in assessments of these patients.