Serum ox-LDL Level is Reduced with the Extent of Stenosis in Coronary Arteries

Oxidized ldl (ox-ldl) lipoproteins are proposed as important modified particles triggering proinflammatory events through receptor-mediated pathways. we evaluated the circulating ox-ldl level on the concept that the chronic immune events may affect ox-ldl clearance as the vessel stenosis develops in coronary arteries. one hundred sixty five subjects underwent coronary angiography and then, subdivided into four subgroups controls (n=85); svd, 2vd and 3vd (n=80). the serum ox-ldl level and other biochemical parameters were measured using elisa method and routine laboratory techniques, respectively. the serum ox-ldl level in the control group (4.81±1.41 mu/mg) was significantly higher than patients (4.28±1.73 mu/mg, p<0.05). the ox-ldl/ldl ratio was conversely reduced with the extent of stenosis as compared with the controls (p<0.05). furthermore, no difference was observed in the ox-ldl/ldl ratio between the 2vd and 3vd patients. we suggested the atherosclerosis process increases the total clearing capacities of the circulating ox-ldl particles.