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Serum Ox-Ldl Level Is Reduced With the Extent of Stenosis in Coronary Arteries
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نویسنده
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Najafi Mohammad ,Alipoor Behnam
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منبع
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Acta Medica Iranica - 2013 - دوره : 51 - شماره : 5 - صفحه:314 -319
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چکیده
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Oxidized ldl (ox-ldl) lipoproteins are proposed as important modified particles triggering proinflammatory events through receptor-mediated pathways. we evaluated the circulating ox-ldl level on the concept that the chronic immune events may affect ox-ldl clearance as the vessel stenosis develops in coronary arteries. one hundred sixty five subjects underwent coronary angiography and then, subdivided into four subgroups controls (n=85); svd, 2vd and 3vd (n=80). the serum ox-ldl level and other biochemical parameters were measured using elisa method and routine laboratory techniques, respectively. the serum ox-ldl level in the control group (4.81±1.41 mu/mg) was significantly higher than patients (4.28±1.73 mu/mg, p<0.05). the ox-ldl/ldl ratio was conversely reduced with the extent of stenosis as compared with the controls (p<0.05). furthermore, no difference was observed in the ox-ldl/ldl ratio between the 2vd and 3vd patients. we suggested the atherosclerosis process increases the total clearing capacities of the circulating ox-ldl particles.
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کلیدواژه
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Cad; Ox-Ldl/Ldl; Stenosis
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آدرس
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Iran University Of Medical Sciences, Cellular And Molecular Research Center, Department Of Biochemistry, ایران, Iran University Of Medical Sciences, Cellular And Molecular Research Center, Department Of Biochemistry, ایران
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Authors
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