A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2)

Acute myeloid leukemia (aml) with t(8;21)(q22;q22) generating the aml1/eto fusion gene on 8q22 is a distinct type of aml t(8;21) category (who)/aml-m2 (fab), generally associated with a favourable prognosis. variant additional chromosomal abnormalities are frequently reported. we report three adult cases of this category with unusual karyotype. bone marrow cytogenetics of case no. 1: 45,x,-y, t(8;21)(q13;q22) with a novel breakpoint of chromosome 8 at (q13). case no. 2: 46,x,t(x;2)(q22;q37),t(3;7)(q21;q36),t(5;14)(p15;q11),del(8)(q22) a complex rearrangement without the involvement of chromosome 21. case no. 3: 49,xx,+5, t(8;21)(q22;q22), +16, +der(21)t(8;21)(q22;q22) with additional der(21). endometrial in this case which was positive for myeloperoxidase (mpo) and cd117 conforming the aml infiltration. all are morphologically aml with t(8;21). relevant literature in cytogenetic of aml-m2 is reviewed. the molecular mechanism involved in unusual rearrangements and clinical significance of them are subjected for further studies.