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Effect of Topical Application of Silymarin (Silybum marianum) on Excision Wound Healing in Albino Rats
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نویسنده
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Sharifi Roya ,Rastegar Hossein ,Kamalinejad Mohammad ,Dehpour Ahmad Reza ,Tavangar Mohammad ,Paknejad Maliheh ,Mehrabani Natanzi Mahboobeh ,Ghannadian Naghmeh ,Akbari Minoo ,Pasalar Parvin
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منبع
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acta medica iranica - 2012 - دوره : 50 - شماره : 9 - صفحه:583 -588
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چکیده
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Silymarin, an extract from silybum marianum, has been shown to have antioxidant properties. however, there is no scientific report on wound healing activity of the silymarin. the purpose of this study was to evaluate the effect of topical administration of silymarin on excision wound healing in rats. excision wounds were made on the back of rats. rats were divided into three groups, as control, vehicle, and treatment. vehicle and treatment groups received polyethylene glycol and silymarin dissolved in polyethylene glycol, respectively. the control group did not receive any treatment. the wound tissues were removed on 5th, 10th and 15th day for histopathological analysis and total collagen determination by hydroxyproline assay. results showed that silymarin increased epithelialization and decreased inflammation but did not have any effect on percentage of wound contraction, collagenization and hydroxyproline levels. it was concluded that silymarin can significantly stimulate epithelialization and reduce inflammation in full-thickness wounds in rats.
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کلیدواژه
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Epithelialization; Excision wound; Silymarin; Wound healing
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آدرس
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tehran university of medical sciences tums, School of Medicine, Department of Biochemistry, ایران, Ministry of Health and Medical Education, Food and Drug Laboratory and Research Center, ایران, shahid beheshti university of medical sciences, School of Pharmacy, Department of Pharmacognosy, ایران, tehran university of medical sciences tums, Department of Pharmacology, ایران, tehran university of medical sciences tums, School of Medicine, Department of Biochemistry, ایران, tehran university of medical sciences tums, School of Medicine, Department of Biochemistry, ایران, tehran university of medical sciences tums, School of Medicine, Department of Biochemistry, ایران, tehran university of medical sciences tums, Scientific Research Center, ایران, Ministry of Health and Medical Education, Food and Drug Control Laboratory and Research Center, ایران, tehran university of medical sciences tums, School of Medicine, Center for Research on Occupational diseases, Department of Biochemistry, ایران
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Authors
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