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blood indoxyl sulfate and tgf-β1 protein and mrna levels in chronic kidney disease: updated insights
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نویسنده
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nazarinasi farhad ,gerayeshnejad siavash ,dashti nasrin ,rahbar khosrow
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منبع
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acta medica iranica - 2025 - دوره : 63 - شماره : 4 - صفحه:231 -236
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چکیده
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Chronic kidney disease (ckd) is characterized by systemic inflammation and the accumulation of uremic toxins such as indoxyl sulfate (is), which induces fibrogenic signaling via transforming growth factor-beta 1 (tgf-β1). forty ckd patients and ten healthy controls were enrolled. is was measured by hplc, tgf-β1 protein by elisa, and tgf-β1 mrna by rt-qpcr in pbmcs. is and tgf-β1 mrna levels increased significantly with ckd stage, particularly in stages 3 and 4. tgf-β1 mrna correlated with is levels (r=0.4, p<0.01), while tgf-β1 protein levels were associated with platelet count (r=0.817, p<0.001). tgf-β1 mrna in pbmcs may serve as an early biomarker of ckd-related fibrosis. is is a key uremic toxin influencing fibrogenic gene expression.
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کلیدواژه
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chronic kidney disease (ckd); indoxyl sulfate (is); tgf-β1 (transforming growth factor-beta1) mrna; fibrosis; pbmcs (peripheral blood mononuclear cells); uremic toxins; biomarkers
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آدرس
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tehran university of medical sciences, school of medicine, department of biochemistry, iran, tehran university of medical sciences, school of medicine, department of biochemistry, iran, tehran university of medical sciences, school of allied medical sciences, department of laboratory science, iran, mehrad hospital, department of nephrology and urology, iran
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پست الکترونیکی
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kh.rahbar56@gmail.com
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Authors
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