comparison of hemodynamic effects of dose response vs. conventional dosing of propofol for anesthesia induction under bispectral index monitoring: a clinical trial

Propofol is an advantageous agent for anesthesia induction. it can cause dose-related hemodynamic adverse effects. the bispectral index (bis) is a brain function monitor utilized to assess the depth of anesthesia. this study aimed to compare the adverse hemodynamic effects of bis-guided response dosing with conventional weight-based dosing of propofol. in this clinical trial, patients were anesthetized with propofol in two different orthopedic operating rooms. in one operating room, patients received propofol with dose-response method (group a), and the other received weight-based dosing (group b). for both groups, bis was used as an index of anesthesia depth. hemodynamic parameters were recorded at baseline, during induction, and at different time points. a total of 73 patients were included in the final analysis. the mean dose of propofol for induction was higher in the control group than in the response-guided group (1.94±1.65 vs. 1.09±0.32, respectively, p=0.006). there were no reported significant adverse hemodynamic effects in patients of the two groups. response-guided propofol dosing can be used to decrease propofol dose during anesthesia induction. further studies are needed to investigate the clinical benefit of this dosing strategy.