assessment of correlations between neonatal jaundice and phototherapy with childhood diabetes type 1

Previous investigations have indicated an association between modulation of developing the immune system with increased risk of autoimmune diseases such as type 1 diabetes mellitus (t1dm). objectives: in the present study, we aimed to evaluate correlations between the positive history of blood group incompatibility, neonatal jaundice, and phototherapy with childhood type 1 dm. a case-control retrospective study was carried out in an iranian hospital in 2015. one-hundred subjects aged 1-15 years with t1dm were included as the case group. one-hundred healthy children were also considered as the control group. a questionnaire composed of demographic-clinical data was completed for each subject. correlations between childhood type 1diabetes and some clinical risk factors were determined. one hundred cases with type 1 diabetes and 100 healthy control children entered the study. a significant association between maternal gestational diabetes mellitus and childhood t1dm was observed (p=0.05, or=3.789). the history of neonatal jaundice in the case group was significantly higher than in the control group (p=0.02, or=4.667). abo incompatibilities in the case group were associated with 19 neonates with blood group a and 2 neonates with blood group b (mothers' blood group; o) (p=0.005, or=7.397). in the case group, 29 of 38 cases with a history of jaundice had received phototherapy while in the control group, 19 participants had undergone phototherapy (p=0.126, or=1.707). results have indicated that neonatal jaundice and abo incompatibility could increase the risk of childhood t1dm. moreover, maternal gdm should be considered as an increased subsequent risk of childhood t1d.