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Calcium Based Non-viral Gene Delivery: An Overview of Methodology and Applications
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نویسنده
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Khosravi-Darani Kianoush ,Mozafari Mohamaad Reza ,Rashidi Ladan ,Mohammadi Mehrdad
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منبع
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acta medica iranica - 2010 - دوره : 48 - شماره : 3 - صفحه:133 -141
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چکیده
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Application of therapeutic gene transfer in the treatment of genetic diseases is a notable progress but there are some disadvantages and limitations in it. the process of overcoming these barriers is a drastic change in gene delivery. recently, calcium phosphate nanoparticles alone, or in combination with viral and nonviral vectors, were found to have a positive effect on gene transfer especially when incorporated in the colloidal particulate systems. this review elaborates on various successful methods of using calcium phosphate nanoparticles in gene delivery, which are considered an advancing approach to gene delivery.
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کلیدواژه
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Calcium phosphate; nanoparticles; gene transfer techniques; transfection
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آدرس
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shahid beheshti university of medical sciences, National Nutrition and Food Technology Research Institute, ایران, Monash University, Department of Biochemistry and Molecular Biology, Australia, Institute of Standard and Industrial Research of Iran, Department of Food & Agriculture Research, ایران, shahid beheshti university of medical sciences, National Nutrition and Food Technology Research Institute, ایران
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پست الکترونیکی
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kiankh@yahoo.com
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Authors
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