Adverse Reactions of Trivalent Influenza Vaccine in HIV-Infected Individuals

In this study, we assessed the adverse reactions to influenza vaccination in hiv- in- fected individuals. from november 2006 to january 2007, a total of 203 hiv-infected persons were recruited. demographic data were collected. subjects were evaluated 48 h and 15 days after vaccination for symptoms and significant health events as possible side effects. participants were instructed to measure their temperature in the morning and evening for 2 days post-immunization and to assess injection site and systemic adverse reactions. 80.3% of the subjects were male. the mean age of the subjects was 36.9±7.9 years. local and systemic reactions were reported by 61 (30%) and 62 (30.5%) persons, respectively. the most common adverse reactions to the influenza vaccine included skin redness (37 cases), induration (32 cases), and pain (55 cases) as local reac- tions, and fever (22 cases), myalgia (46 cases), headache (12 cases) and weakness (35 cases) as general reactions. 1.4 % of the subjects had fever over 38.5 ؛c. there were significant associations between myalgia and flushing with cd4 counts (p<0.05). we found no relationship between ad- verse reactions and sex, history of smoking, allergy, alcohol, and drug usage, stage of hiv infec- tion, anti-retroviral therapies, anti-tb medication and previous vaccination. we concluded that in- activated influenza vaccine administered in hiv-infected adults did not result in potential adverse events in this study population.