EVALUATION OF IL1-alpha AND TNF-alpha SERUM LEVELS IN RHEUMATOID ARTHRITIS PATIONTS WITH ACTIVE AND INACTIVE, WITH OR WITHOUT BONE EROSION

Rheumatoid arthritis is the most common inflammatory joint disease with 1 percent prevalence in community which presents with symmetrical polyarthritis of hands with inflammatory behavior. several studies in recent years were conducted for evaluation of inflammatory cytokines such as il1-alpha(interleukin 1&) and tnf-alpha (tumor necrosis factor) in rheumatologic disorders including rheumatoid arthritis to find new treatment methods base to pathogenesis. in this study different serum levels of il1-alpha and tnf-alpha in 160 rheumatoid arthritis patients with active and inactive disease and also disease with or without bone erosion are assessed. 4% of our patients had rheumatoid nodule and 70% of all patients had positive rf, il1-&, and tnf-alpha levels. active with bone erosion patients had il1-alpha and tnf-alpha serum levels higher than active without bone erosion patients; it was not significant in t- test but it was significant in mann-whitney test. the results was the same as expected; il1-&, and tnf-alpha serum levels were higher in active with bone erosion in comparison with inactive without bone erosion patients.