Preptin and Myostatin Independently Increase in Pre-Diabetics and Patients of Type 2 Diabetes Mellitus

The relation between serum preptin, myostatin, insulin, and also homeostatic model assessment-insulin resistance were examined in pre-diabetes persons and newly diagnosed patients with overt type 2 diabetes mellitus. a total of 84 subjects were included in the study and assigned into three groups: normoglycemic participants (group 1=27), pre-diabetes (group 2=30), and t2dm (group 3=29). serum insulin, preptin, and myostatin levels were measured with immunoradiometric assay (irma), enzyme-linked immunosorbent assay (elisa), and chemiluminescent immunoassay (clia), respectively. patients with t2dm had higher levels of preptin compared to normoglycemic (461.25±53.90 vs. 407.54±54.78, p<0.001). furthermore, these patients had elevated levels of myostatin compared with controls (2710.60±559.09 vs. 2246.37±416.40, p<0.001). preptin and myostatin both positively correlated with serum insulin (r=0.369, p=0.01, and r=0.309, p=0.04, respectively). however, no significant association was found between serum preptin and myostatin levels. stepwise multiple regression analysis showed that insulin was affected more by preptin, with only a trivial contribution from myostatin. serum preptin and myostatin levels increase in pre-diabetic subjects and even further in type 2 diabetic patients. the correlation between preptin and insulin evolves when pre-diabetes or overt type 2 diabetes develops. moreover, serum myostatin increases in association with insulin and not homa-ir in diabetic conditions.