vitamin d level and vitamin d receptor gene polymorphisms in iranian azeri turkish patients with autoimmune thyroid diseases

The autoimmune thyroid diseases (aitds) are among the most common endocrine disorders. vitamin d as an immunomodulator and vitamin d receptor (vdr) gene polymorphisms may be effective in aitds pathogenesis. the aim of this study was to evaluate the vitamin d level and vdr bsmi and taqi polymorphisms in iranian azeri turkish patients with aitds. this case-control study included 121 adults with aitds and 117 non-aitds controls. serum level of 25-hydroxyvitamin d was measured by electrochemiluminescence (ecl) immunoassay. bsmi and taqi polymorphisms were assessed by polymerase chain reaction fragment length polymorphism technique. the serum level of 25-hydroxyvitamin d in aitds patients were lower than controls (p=0.03). the frequencies of tt, tc, cc, t and c genotypes/alleles at taqi (rs731236) marker were 52.1%, 34.7%, 13.2% , 69.4% and 30.6% in aitds and 44.4%, 41.9%, 13.7%, 65.4% and 34.6% in controls, respectively. the frequencies of aa, ag, gg, a and g genotypes/alleles at bsmi (rs1544410) marker were 14%, 64.5%, 21.5% , 46.3% and 53.7% in aitds and 26.5%, 58.1%, 15.4%, 55.6% and 44.4% in controls, respectively. bsmi (rs1544410) gg+ag genotypes and g allele were more frequent among patients with hashimoto compared with control group (86.6% vs. 73.5% (or: 2.34, 95% ci: 1.16-4.70, p = 0.014) and 54.29% vs. 44.44% (or: 1.48, 95% ci: 1.02-2.15, p = 0.038), respectively). vitamin d status can be related to aitds pathogenesis. bsmi (rs1544410) gg+ag genotypes and g allele may play an important role in the predisposition to hashimoto.