Spectrophotometric Determination of Allopurinol in Tablet Formulation

A new spectrophotometric method for the determination of allopurinol drug was investigated. the proposed method was based on the reaction of the intended drug with catechol and fe(ii) to form a blue soluble complex which was measured at ëmax 580 nm. a graph of absorbance versus concentration shown that beer’s law was obeyed over the concentration range of 2–10 µg ml–1 with molar absorptivity of 9.4 x 103 l mol–1 cm–1 and sandell sensitivity of 1.4 x 10–2 µg cm–2. a recovery percentage of 100% with rsd of 1.0%–1.3% was obtained. the proposed method was applied successfully for the determination of allopurinol drug in tablets with a good accuracy and precision. the optimum condition for the color development has also been investigated.